"Kelly Osbourne is departing E!s Fashion Police to pursue other opportunities," says E! Entertainment in a terse statement.
"We would like to thank her for her many contributions to the series over the past five years, during which time the show became a hit with viewers," says E! Entertainment.
E! Entertainment and Fashion Police announced no replacement for Kelly Osbourne.
There won't be any formal proper on-air goodbye, reflecting clip show or any of the usual proper farewells when an on-air TV talent leaves - indicative of the rancour and bitterness behind the Fashion Police scenes.
According to TMZ, citing multiple sources Kelly Osbourne has been wanting to get off Fashion Police since the reset without Joan Rivers and that tension started from the first episode of the "new" Fashion Police with Brad Goreski and Kathy Griffin and without Joan Rivers and George Kotsiopoulos in January.
According to multiple sources Kelly Osbourne was unhappy with how Fashion Police was being produced since 2015, and the E! Entertainment show's producers were equally unhappy with Kelly Osbourne's on-set attitude.
Kelly Osbourne's abrupt departure leaves the severely compromised Giuliana Rancic as the only remaining original member on the struggling fashion critique comedy show following her highly offense comments earlier the week.
Earlier the week Kelly Osbourne threatened to quit the show following Giuliana Rancic's racist comments and has now made good on her threat to dump Fashion Police, hurling ultimatums and saying "I'm giving everyone involved 24 hours to make it right or the world will hear how I really feel. Contractually I'm not allowed to speak!"
Kelly Osbourne tweeted that "I'm seriously questioning staying on the show!"
The backstage atmosphere at E! Entertainment's Fashion Police, produced by the late Joan Rivers' daughter Melissa Rivers, has been fraught with tension and scandal since Giuliana Rancic on Monday called Zendaya's dreadlocks looking like "she smells like patchouli oil" or "weed".
Giuliana Rancic, who is also the anchor of eNews on E! Entertainment damaged her credibility and reputation although she did apologise on Tuesday on eNews for her controversial remarks.
An insider told publication Us Weekly on Saturday that "Kelly hasn't been happy at the show for a while," and that "this whole situation solidified her decision to move on. It was time for her to go. She had five great years there, and the relationship she had with Joan there changed her life."