Lesego Motsepe (39) is known for her portrayal of the character of Letti Matabane from 1993 to 2008, and in 2011 became South Africa's first TV soap star to publicly announce that she was HIV positive.
"We are saddened by the news of Lesego’s sudden passing at such a young age," says Sivan Pillay, Endemol South Africa's managing director.
"During her years on Isidingo, she was professional and performed to the best of her abilities. We extend our grief and sincere condolences to her family and friends. She will be missed by her friends and colleagues here at Endemol."
Sivan Pillay says Lesego Motsepe "performed well in her craft, and delivered her role exceptionally. Endemol and Isidingo's cast and crew will celebrate her contributions to the show. Her legacy, love and influence in acting will remain in the lives and hearts of many South Africans."
The SABC is also reacting to Lesego Motsepe's death.
The SABC says Lesego Motsepe "will be truly missed".
"As the SABC we are proud to have contributed to the nurturing of this fine talent. The corporation would like to send heartfelt condolences to Lesego Motsepe's family, friends and colleagues. Lesego Motsepe will be remembered for her immense contribution in the arts industry."
"Her face will surely disappear from our minds, but her great work will remain and continue to challenge and inspire new and established performers," says the SABC.
